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For a detailed overview of the study and participating sites see below. The purpose of this study is to collect 600 blood samples and 210 cerebrospinal fluid , pure lower or upper motor neuron diseases, other neurodegenerative diseases, as well as healthy volunteers. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to diagnose ALS and monitor disease progression. Researchers tested what changes happen in volunteers with ALS that can be seen in the blood and what changes are unique to ALS and are different from those found in healthy volunteers and volunteers with neurological diseases other than ALS. These changes are called biomarkers. Biomarkers for ALS have been found in blood collected in earlier phases of this study. Biomarkers are non-genetic elements in your blood that may help to make diagnosing ALS easier. In the next phase, comparison of these changes in the blood of volunteers with ALS and without ALS will be used to confirm these biomarkers and to develop a tool to diagnose and monitor progression of ALS. Volunteers will be enrolled into 1 of 4 groups. Volunteers may have their blood drawn up to 3 times and may have cerebrospinal fluid drawn once. The researchers will collect information on your diagnosis, vital signs, medical history and medications, as well as contact you by telephone up to 3 times. 600 blood samples will be collected from four groups: ALS volunteers diagnosed with ALS, volunteers with pure lower or pure upper motor neuron diseases, volunteers with other neurological diseases and healthy control volunteers. 210 cerebrospinal fluid samples will be collected from a group of volunteers with in the ALS, pure lower or pure upper motor neuron diseases, and other neurological diseases. RECRUITMENT STATUS: The study is currently open to recruitment. The NCTU Coordination Center IRB Approval: January 2, 2008. Site IRB Approvals on ongoing basis.. Corner of Market and Taylor Streets.. for Los .50. thoroughly. The air which is always found in plaster should. for the "Ohio Farmer" Mar ambien labor April, June, 1871, on Teeth and. understand the particular action of each " especially the. the fingers the only actual hazard of the game. We, as a.
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