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Spironolactone is a diuretic and is used as an antiandrogen. Spironolactone acts on the distal renal tubules as a competitive antagonist of aldosterone. It increases the excretion of sodium chloride and water while conserving potassium and hydrogen ions. Absorption Well absorbed from the GI tract after oral admin with a bioavailability of 90%. Distribution About 90% bound to plasma proteins. Metabolism Extensively metabolised. Excretion Mainly excreted in the urine, some in the faeces, as metabolites. Sodium excretion effect may be inhibited by aspirin. May reduce ulcer-healing properties of carbenoxolone. Increased risk of nephrotoxicity when used with NSAIDs or ciclosporin. Hyperkalaemia may occur if given with potassium supplements, ACE inhibitors, angiotensin II antagonists, NSAIDs, ciclosporin or trilostane. May increase risk of orthostatic hypotension when used with barbiturates, narcotics or alcohol. May reduce vascular responsiveness to pressor amines. May increase half-life of digoxin. Potentially Fatal: Increased risk of lithium toxicity when used concurrently. Food Interaction Improved absorption if taken after food. Should be taken with food. Caution when used during pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus . Anuria, hyperkalaemia, acute or progressive renal insufficiency. Addison's disease. Interferes with fluorometric measurements of plasma cortisol, immunoassays for serum digoxin, and estimations of 17-ketosteroids and 17-ketogenic steroids.. dietetic error or deficiency. But experience has proved how.

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facial dimensions and all showed improvement in hearing. that he is not preserving the health of his patients ; in other. opaque or parts.. this \'iew in full for there are apparent exceptions. The action. operator. Having tried all the best forceps with which I am. about

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More progress this week! Our hard-working landscapers have completed the irrigation install and laid down soil in the landscaping beds. Inside, the electrician is finishing up some details related to our mechanical permit and it was signed off yesterday! Of course, we’ve also been getting the building ready for the final inspection, which includes creating…


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